CALL FOR PAPERS Novel Therapeutics In Renal Diseases IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats
نویسندگان
چکیده
Zuzana Kadova, Eva Dolezelova, Jolana Cermanova, Milos Hroch, Tomas Laho, Lucie Muchova, Frantisek Staud, Libor Vitek, Jaroslav Mokry, Jaroslav Chladek, Zuzana Havlinova, Milan Holecek, and X Stanislav Micuda Department of Pharmacology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic; Department of Medical Biochemistry, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic; Department of Histology and Embryology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic; Department of Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic; Department of Pharmacology and Toxicology, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic; Department of Biological and Medical Sciences, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Hradec Kralove, Czech Republic; Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; and 4th Department of Internal Medicine, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
منابع مشابه
IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats.
The aim of our study was to investigate whether two potent anti-inflammatory agents, dexamethasone and anakinra, an IL-1 receptor antagonist, may influence acute kidney injury (AKI) and associated drug excretory functions during endotoxemia (LPS) in rats. Ten hours after LPS administration, untreated endotoxemic rats developed typical symptoms of AKI, with reduced GFR, impaired tubular excretio...
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تاریخ انتشار 2015